On April 13, 2010, the Center on Children and Families at Brookings and the Center for the Study of Poverty and Inequality at Stanford University sponsored an event that focused on the science of early brain development and the role that chronic stress early in life plays in the arrested development of children raised in risky situations. The policy implications of these and similar findings were discussed. This segment features Nathan A. Fox, Professor, University of Maryland, describing pioneering work that he and his colleagues carried out in Bucharest, Romania, looking at how institutionalization of children can profoundly harm children’s brain development.