Individuals detained by US Immigration and Customs Enforcement (ICE) live in congregate settings and thus have a disproportionately high risk of contracting coronavirus disease 2019 (COVID-19). To reduce spread of COVID-19, ICE published its Pandemic Response Requirements in April 2020. These requirements established social distancing and disinfection protocols, testing guidelines, and expedited detainee release. This analysis examined COVID-19 testing and cases per month among ICE detainees.